Chronic diseases place a major burden on individuals and challenge thin-stretched health systems in low- and middle income countries. Sustainable, cost-effective approaches to providing high-quality prevention and care are thus urgently needed. The Clinical Research Global Health (CRGH) contributes evidence towards better understanding and addressing public health challenges through clinical, epidemiological, and implementation research, including individual- and cluster-randomised controlled trials, cohorts, and scoping or systematic reviews. We focus primarily on communicable and non-communicable chronic conditions in Southern and East Africa; building on our experience and ongoing work in strengthening the HIV care cascade from diagnosis to viral suppression, we are transferring learnings to health service provision for cardiovascular diseases. We partner with non-governmental organisations, healthcare facilities, and Ministries of Health for the implementation and to promote sustainability of our projects.